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MTP inhibition induces ER stress and increases gene transcription via Ire1α/cJun to enhance plasma ALT/AST

Abbreviations used: ALT, Alanine aminotransferase; ApoB, Apolipoprotein B; AST, Aspartate aminotransferase; ER, Endoplasmic Reticulum; GPT, Glutamic Pyruvic Transaminase; GOT, Glutamic Oxaloacetic Transaminase; GSH, Reduced glutathione; HDL, High density lipoprotein; HMGR, HMG-CoA reductase; LDH, lactate dehydrogenase; Lo, Lovastatin; MTP, Microsomal triglycerides transfer protein; MTPi, MTP in...

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ALT: Another Likelihood Tool

Although there are many phylogenetic reconstruc-tion tools available [1][4], their purpose is in generalto solve specific problems or to apply a limited num-ber of evolution models.We present a new program, ALT — AnotherLikelihood Tool, which implements Felsenstein’smaximum likelihood algorithm [2][3] two importantcharacteristics: it is written in a highly modular<lb...

ALT text and basic accessibility

Recent surveys have shown that the majority of websites are not accessible. Despite legal obligations and the importance of the internet for disabled people, most websites fail to reach a basic level of accessibility, yet web developers are not short of accessibility guidelines and recommendations. This preliminary study consists of a meta-review of web accessibility studies in order to identif...